?Sr. Principal Infrastructure Architect – Manufacturing & Quality Systems

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: January 3, 2026

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Sr. Principal Infrastructure Architect – Manufacturing & Quality Systems At Lilly, we unite caring with discovery to make life better for people around the world. As we continue enabling advanced manufacturing capabilities, we are seeking a Sr. Principal Infrastructure Architect to provide strategic technology leadership across Indianapolis Parenteral Manufacturing (IPM), Indianapolis Device Assembly & Packaging (IDAP), and Indianapolis Device Manufacturing (IDM). What You'll Be Doing The Sr. Principal Infrastructure Architect will design and govern IT infrastructure supporting GMP-regulated manufacturing execution, laboratory, and quality systems. You will ensure resilient, secure, and compliant platforms that enable operational reliability and digital transformation. Key Responsibilities • Develop and maintain infrastructure architecture roadmaps for IPM, IDAP, and IDM, aligned with Tech@Lilly strategy.• Lead infrastructure readiness for the transition from PMX to PharmaSuite and other key MES modernization initiatives.• Architect secure, validated networking, compute, storage, and virtualization platforms supporting MES, EWM/WMS, Quality Systems, and S95 Level 2 solutions.• Provide technical leadership and escalation support for complex operational and cybersecurity challenges.• Ensure compliance with GMP, GxP, CSV, and data integrity standards.• Lead major infrastructure deployments and modernization programs across all three manufacturing areas.• Partner with operations, engineering, automation, cybersecurity, and global architecture teams to deliver scalable solutions.• Excellent communication and executive influence skills.• Strong analytical capabilities with a proven track record of solving complex operational technology challenges.• Experience working in fast-paced, operationally critical environments with multiple stakeholders and competing priorities. Basic Requirements • Bachelor's degree in Computer Science, Engineering, Information Systems, or related field.• 5 years of experience architecting IT infrastructure in GMP-regulated pharmaceutical or advanced manufacturing environments.• 2 years of working with MES, EWM/WMS, DCS, Industrial IoT networks, and S95 Level 2 architectures. Additional Skills & Preferences • Demonstrated ability to lead multi-site infrastructure programs and influence executive technology decisions.• Expertise in secure architecture design, disaster recovery, and operational resiliency.• Experience supporting parenteral and/or device manufacturing.• Familiarity with PharmaSuite, PMX, SAP EWM, or other MES/WMS platforms.• Certifications or networking/security credentials preferred.• Experience with hybrid cloud models, edge technology, and modern cybersecurity controls.• Strong interpersonal skills and ability to build capability within teams through coaching and thought leadership. Join Us This role offers the opportunity to shape the digital foundation that enables Lilly to reliably deliver life-changing medicines for patients around the world. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $126,000 - $224,400 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

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